CBD Isolate Applications & Use Cases - Formulation Examples

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Tinctures & Oils

Oil-based sublingual formulations for rapid absorption

Example Formulation: 1000mg CBD Tincture (30ml)

Ingredient	Quantity	% by Weight	Purpose
CBD Isolate (99.5% purity)	1.005g	3.4%	Active ingredient
MCT Oil (C8/C10)	27.50g	94.1%	Carrier oil, bioavailability
Natural Flavor (optional)	0.75g	2.5%	Taste enhancement
Total	29.255g	100%	~30ml at 0.975 g/ml

CBD Concentration 33.3 mg/ml

Serving Size 1ml (~30 drops)

CBD per Serving 33.3mg

Servings per Bottle 30

💡 Manufacturing Tip: Heat MCT oil to 60-65°C before adding CBD isolate. Stir continuously until fully dissolved (typically 10-15 minutes). Allow to cool to 40°C before adding heat-sensitive flavoring. Filter through 0.22μm if sterile fill is required.

Processing Parameters

Dissolution Temperature: 60-70°C
Mixing Time: 15-20 minutes with continuous agitation
Cooling: Cool to <40°C before bottling
Fill Temperature: Room temperature (20-25°C)
Stability: 24+ months when stored cool, dark, sealed

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Topicals & Creams

Emulsified formulations for transdermal application

Example Formulation: 500mg CBD Cream (100g)

Ingredient	Quantity (g)	% by Weight	Function
Oil Phase
CBD Isolate	0.50	0.5%	Active ingredient
Emulsifying Wax NF	8.00	8.0%	Emulsifier
Jojoba Oil	10.00	10.0%	Carrier, skin penetration
Shea Butter	5.00	5.0%	Emollient, consistency
Water Phase
Distilled Water	73.50	73.5%	Continuous phase
Glycerin	2.00	2.0%	Humectant
Cool-Down Phase
Preservative (Leucidal Liquid)	0.50	0.5%	Antimicrobial
Essential Oil Blend	0.50	0.5%	Fragrance, therapeutic
Total	100.00g	100%

CBD Concentration 5 mg/g (0.5%)

Application Amount 1-2g per use

CBD per Application 5-10mg

pH Range 5.0-6.0

💡 Manufacturing Tip: Dissolve CBD isolate in oil phase at 75°C. Separately heat water phase to 75°C. Slowly add water phase to oil phase with high-shear mixing. Cool to 40°C before adding preservative and essential oils. Homogenize for 2-3 minutes for smooth texture.

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Gummies & Edibles

Water-soluble formulations for food products

Example Formulation: CBD Gummies (10mg per piece)

For edibles, CBD isolate must first be converted to a water-dispersible form using nanoemulsion or polysorbate-based solubilization.

Step 1: Water-Soluble CBD Preparation

Ingredient	Quantity	Purpose
CBD Isolate	10.00g	Active ingredient
Polysorbate 80	15.00g	Emulsifier/solubilizer
MCT Oil	5.00g	Lipid carrier
Lecithin	2.00g	Co-emulsifier
Distilled Water	68.00g	Dispersing medium

Step 2: Gummy Base (makes 100 gummies, 10mg each)

Ingredient	Quantity	% by Weight
Gelatin (or Pectin for vegan)	150g	30%
Water	150g	30%
Glucose Syrup	120g	24%
Sugar	60g	12%
Water-Soluble CBD (from above)	10g	2%
Citric Acid	5g	1%
Natural Flavor & Color	5g	1%
Total	500g	100%

CBD per Gummy 10mg

Gummy Weight 5g each

Yield 100 pieces

Shelf Life 12 months

💡 Manufacturing Tip: Bloom gelatin in cold water. Heat to 60°C, add syrups and water-soluble CBD at 50°C. Pour into molds at 45-48°C. Allow to set for 4-6 hours at room temperature. Coat with cornstarch or sour sugar to prevent sticking. Store in airtight containers with humidity control.

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Beverages

Clear, stable CBD nanoemulsions for drinks

Example Formulation: CBD Beverage Concentrate (for dilution)

This concentrate can be diluted 1:10 into water, juice, or other beverages to achieve 10mg CBD per serving.

Ingredient	Quantity	% by Weight	Purpose
CBD Isolate	5.00g	5.0%	Active ingredient
Medium Chain Triglycerides	5.00g	5.0%	Oil phase
Quillaja Extract	2.50g	2.5%	Natural emulsifier
Gum Arabic	1.50g	1.5%	Stabilizer
Glycerin	10.00g	10.0%	Viscosity, preservation
Citric Acid	1.00g	1.0%	pH adjustment, flavor
Natural Flavor	1.00g	1.0%	Taste
Distilled Water	74.00g	74.0%	Carrier
Total	100.00g	100%

CBD Concentration 50 mg/ml

Dilution Ratio 1:10

Final Beverage 5 mg/ml

Particle Size <100nm

💡 Manufacturing Tip: Use high-pressure homogenization (15,000+ PSI) or ultrasonication to achieve <100nm particle size for clear appearance and stability. pH should be maintained between 3.0-4.5 for optimal stability. Pasteurize at 72°C for 15 seconds if shelf-stable product is required.

Key Stability Considerations

pH Sensitivity: Maintain pH 3.0-5.0 for best emulsion stability
Temperature: Avoid freeze-thaw cycles; store at 4-25°C
Light Exposure: Use amber or opaque bottles to prevent oxidation
Shelf Life: 12-18 months refrigerated; 6-9 months ambient

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Cosmetics & Skincare

CBD-infused beauty and personal care products

Example Formulation: CBD Facial Serum (30ml)

Ingredient	Quantity (g)	% by Weight	Function
CBD Isolate	0.30	1.0%	Active, anti-inflammatory
Squalane	9.00	30.0%	Carrier, skin barrier
Rosehip Seed Oil	6.00	20.0%	Regenerative, vitamin A
Jojoba Oil	6.00	20.0%	Emollient, penetration
Vitamin E (Tocopherol)	0.60	2.0%	Antioxidant, preservative
Hyaluronic Acid Solution	4.50	15.0%	Humectant, hydration
Essential Oil Blend	0.30	1.0%	Fragrance, therapeutic
CoQ10	0.15	0.5%	Antioxidant
Niacinamide	0.90	3.0%	Skin brightening
Preservative (optional)	0.15	0.5%	Antimicrobial
Distilled Water	2.10	7.0%	Solvent
Total	30.00g	100%

CBD Concentration 10 mg/ml (1%)

Application Amount 3-5 drops

CBD per Use 1.5-2.5mg

Product Type Anhydrous Oil

💡 Manufacturing Tip: Dissolve CBD isolate in squalane at 60°C. Combine all oil-soluble ingredients, then add water-soluble ingredients. Mix gently to avoid oxidation. Fill into UV-protected dropper bottles. No emulsification required for anhydrous formulations. Shelf life: 18-24 months when protected from light and heat.

Benefits of CBD in Skincare

Anti-inflammatory: Reduces redness and irritation
Sebum regulation: May help balance oil production
Antioxidant: Protects against environmental stressors
Clean label appeal: Natural, hemp-derived active

CBD Isolate Applications